These include kidney disease, liver disease, connective tissue disorders and an underactive thyroid (hypothyroidism). These include an abnormal protein in the blood (monoclonal gammopathies), a form of bone cancer (myeloma), lymphoma and the rare disease amyloidosis. These are a form of a degenerative disorder called paraneoplastic syndrome. Also, polyneuropathy can arise as a result of some cancers related to the body's immune response. Growths, cancerous (malignant) and noncancerous (benign), can develop on the nerves or press on nerves. Disorders such as Charcot-Marie-Tooth disease are hereditary types of neuropathy. These include certain viral or bacterial infections, including Lyme disease, shingles, Epstein-Barr virus, hepatitis B and C, leprosy, diphtheria, and HIV. Among people with diabetes, more than halfwill develop some type of neuropathy. These include Sjogren's syndrome, lupus, rheumatoid arthritis, Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy and vasculitis. Health conditions that can cause peripheral neuropathy include: Peripheral neuropathy is nerve damage caused by a number of different conditions. Early diagnosis and treatment offer the best chance for controlling your symptoms and preventing further damage to your peripheral nerves. Seek medical care right away if you notice unusual tingling, weakness or pain in your hands or feet. Most people with peripheral neuropathy have polyneuropathy. Carpal tunnel syndrome is an example of mononeuropathy. Peripheral neuropathy can affect one nerve (mononeuropathy), two or more nerves in different areas (multiple mononeuropathy), or many nerves (polyneuropathy). Drops in blood pressure, causing dizziness or lightheadedness.Excessive sweating or not being able to sweat.If autonomic nerves are affected, signs and symptoms might include: Feeling as if you're wearing gloves or socks when you're not.Pain during activities that shouldn't cause pain, such as pain in your feet when putting weight on them or when they're under a blanket.Sharp, jabbing, throbbing or burning pain.Gradual onset of numbness, prickling or tingling in your feet or hands, which can spread upward into your legs and arms.Signs and symptoms of peripheral neuropathy might include: Autonomic nerves that control functions such as blood pressure, perspiration, heart rate, digestion and bladder function.Motor nerves that control muscle movement.Sensory nerves that receive sensation, such as temperature, pain, vibration or touch, from the skin.Every nerve in your peripheral system has a specific function, so symptoms depend on the type of nerves affected.
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